IGFs AND IGF BINDING PROTEINS IN HUMAN CORD SERA: RELATIONSHIP TO INTRAUTEINE GROWTH
نویسندگان
چکیده
منابع مشابه
Insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBP-1, -2 and -3) in diabetic pregnancy: relationship to macrosomia.
To evaluate the role of insulin-like growth factors (IGFs) and IGF-binding proteins (IGFBPs) in excessive fetal growth (macrosomia) in diabetic pregnancy, 84 insulin-treated diabetic mothers and their infants were tested for serum concentrations of IGF-I, IFG-II, and IGFBP-1, -2 and -3. These parameters were correlated with the birth weight of neonates and placental weight. IGF-I and II levels ...
متن کاملIGFs and IGF-binding proteins in the regulation of human ovarian and endometrial function.
The key function of reproduction is to propagate inheritable characteristics to new generations. The human female reproductive system consists of the hypothalamic– pituitary–ovarian axis and end organs such as the uterus and fallopian tubes. The endocrine axis involves both peptide hormones (gonadotropin-releasing hormone, follicle-stimulating hormone (FSH) and luteinizing hormone (LH)) and ste...
متن کاملInsulin-like growth factor (IGF)-binding proteins: interactions with IGFs and intrinsic bioactivities.
The insulin-like growth factor (IGF)-binding proteins (IGFBPs) are a family of six homologous proteins with high binding affinity for IGF-I and IGF-II. Information from NMR and mutagenesis studies is advancing knowledge of the key residues involved in these interactions. IGF binding may be modulated by IGFBP modifications, such as phosphorylation and proteolysis, and by cell or matrix associati...
متن کاملPolycystic ovary syndrome (PCOS), insulin resistance and insulin-like growth factors (IGfs)/IGF-binding proteins (IGFBPs).
Polycystic ovary syndrome (PCOS) is the most frequent androgen disorder of ovarian function. Hyperinsulinemia with insulin resistance is believed to be a key link in the enigmatic generation of the symptoms of PCOS such as anovulatory infertility and hyperandrogenism. Regression of these symptoms may be achieved by reducing the hyperinsulinemia. A growing body of evidence suggests that PCOS pat...
متن کاملIGF-I and IGF-binding protein-1 are related to cortisol in human cord blood.
OBJECTIVE To assess cortisol concentrations in cord blood and investigate their relationships with the IGF system. STUDY DESIGN Fifteen newborns with birth weight appropriate for gestational age (AGA) and 30 children with intrauterine growth retardation (IUGR) were studied. Serum samples were collected from umbilical cord blood and cortisol, IGF-I and IGF-binding proteins (IGFBPs)-1 and -3 we...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1993
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199305001-00196